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Treatment with D-penicillamine Improves Dopamine D2-Receptor Binding and T2-Signal Intensity in de novo Wilson's Disease Neurol 44:1079-1082, Schwarz,J.,et al, 1994 See this aricle in Pubmed Article Abstract We report the results of in vitro striatal dopamine D2-receptor binding assessed by PET using C-raclopride(only one patient)and by single-photon emission computed tomography(SPECT)using I-iodobenzamide(I-IBZM)and the findings of T2-weighted MRIs in two de novo Wilson's disease patients before and 4 months after initiation of D-penicillamine treatment.On heavily T2-weighted MRI sequences,hyperintense signal changes before therapy within the putamen(both patients),brainstem(only patient 1),and caudate(only patient 2)greatly diminished after treatment.Reduced striatal dopamine D2-receptor binding in these Wilson's disease patients improved under therapy,suggesting,in part,a reversible defect of striatal neurons.

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(click to filter results - removes previous filter) CAT scan,emission CAT scan,emission,abnormal dopamine receptor,D2 hepatolenticular degeneration(Wilson's disease) MRI MRI,abnormal penicillamine single photon emission computed tomography

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